Traumatic brain injury (TBI) is a major health problem affecting more than 8 million European and becoming a challenge for the health systems. Patients affected by TBI show serious neurological disorders such as decision-making and memory deficits, depression or aggressive behavior.
Several of the important brain functions affected by TBI depend on the hippocampus, a brain structure very important for memory and learning that is highly vulnerable to injury. Importantly, In the hippocampus contains neural stem cells (NSC), capable of generating new neurons.
TBI may induce long-term changes in NSCs and new neurons born from them, subsequently impairing hippocampal and brain functioning. We aim to understand what particular changes are induced by TBI, and what is their actual impact on brain functioning and behavior.
Based on these ideas, we propose that NSCs should be considered a novel target for developing innovative strategic therapies against brain damage induced after TBI.